Bioinformatics and Systems Biology Lab | BioSys_BUT

Groupleader
doc. Mgr. Ing. Karel Sedlář, Ph.D.

Main research areas

  • Processing data from NGS and TGS sequencing.
  • Development of algorithms for the inference and analysis of biological regulatory networks.
  • Computational tools for routine clinical microbiology and epidemiology.
  • Genotyping of new bacterial strains and their functional system description.
  • Analysis of microbial communities from various environments.
  • Multi-target drug design using chemoinformatics approaches.
  • Design and development of custom tools for qualitative and quantitative analysis of laboratory data.

Main practical research results

  • Augusta: A computational tool for inferring gene regulatory networks, constructing Boolean models, and searching for transcriptional motifs.
  • Publicly available database of genomes from 46 ESBL Klebsiella pneumoniae strains from the hospital population of FN Brno with very low diversity.
  • Publicly available database of genomes from hundreds of multi-resistant Enterococcus faecium and Escherichia coli strains from the hospital population of FN Brno.
  • Complete and publicly available annotated genomes of dozens of bacteria.
  • CNproScan and ProcaryaSV: A tool and computational pipeline for detecting structural variants such as tandem and dispersed repeats, multiplications, and deletions across bacterial genomes.

Main research publications

Projects/Industrial contracts